三法联合治疗青少年特发性脊柱侧弯的疗效及对肺功能的影响

目的探讨整脊手法配合三维牵引及矫形支具(三法联合)治疗青少年特发性脊柱侧弯( AIS)临床疗效及对肺功能的影响。方法选取 2018年 6月至 2020年 1月承德医学院附属医院收治的 76例 AIS病人作为研究对象,按照随机数字表法分为两组,每组 38例。对照组采用三维牵引及矫形支具进行治疗,观察组在对照组基础上配合整脊手法进行治疗;治疗 3个月,察治疗前后病人 Cobb角及肺功能相关指标用力肺活量( FVC)、第 1秒用力呼气容积( FEV1)、每分钟最大通气量( MVV)的变观化。结果两组病人治疗后的 Cobb角均低于治疗前,其中观察组治疗后 Cobb角为( 7.93±2.15)°,对照组治疗后 Cobb角为(12.05±3.45)°,观察组治疗后 Cobb角显著低于对照组,差异有统计学意义( P<0.05);观察组病人整体疗效优于对照组,且观察组总有效率［ 84.21%(32/38)］高于对照组总有效率［ 60.53%(23/38)］,差异有统计学意义( P<0.05)。对照组治疗后 FVC、FEV1、 MVV均较治疗前下降,差异有统计学意义( P<0.05);观察组治疗后各指标均高于治疗前,差异有统计学意义( P<0.05)。结论三法联合治疗 AIS,临床疗效显著,且能够有效改善病人肺功能。     

“六步八法”手法联合阿仑膦酸钠治疗膝关节退行性病变

目的探讨"六步八法"手法联合阿仑膦酸钠治疗膝关节退行性病变临床疗效。方法随机将2012-03—2014-03间收治的60例膝关节退行性病变患均分为对照组和观察组,每组30例。对照组行阿仑膦酸钠治疗,观察组则给予"六步八法"手法联合阿仑膦酸钠治疗。对2组临床疗效、治疗前后VAS及JOA评分进行比较。结果观察组治疗总有效率96.67%,明显高于对照组(80.00%)。两组比较,差异有统计学意义。2组治疗后VAS及JOA评分比较差异有统计学意义(P<0.05)。结论 "六步八法"手法联合阿仑膦酸钠治疗膝关节退行性病变安全有效,能明显改善患者膝关节功能,值得临床推广。     

Distinct Biomarker Profiles in Ex Vivo T Cell Depletion Graft Manipulation Strategies: CD34+ Selection versus CD3+/19+ Depletion in Matched Sibling Allogeneic Peripheral Blood Stem Cell Transplantation

Various approaches have been developed for ex vivo T cell depletion in allogeneic stem cell transplantation to prevent graft-versus-host disease (GVHD). Direct comparisons of T cell depletion strategies have not been well studied, however. We evaluated cellular and plasma biomarkers in 2 different graft manipulation strategies, CD3⁺CD19⁺ cell depletion (CD3/19D) versus CD34⁺ selection (CD34S), and their associations with clinical outcomes. Identical conditions, including the myeloablative preparative regimen, HLA-identical sibling donor, GVHD prophylaxis, and graft source, were used in the 2 cohorts. Major clinical outcomes were similar in the 2 groups in terms of overall survival, nonrelapse mortality, and cumulative incidence of relapse; however, the cumulative incidence of acute GVHD trended to be higher in the CD3/19D cohort compared with the CD34S cohort. A distinct biomarker profile was noted in the CD3/19D cohort: higher levels of ST2, impaired Helios^? FoxP3⁺Treg reconstitution, and rapid reconstitution of naïve, Th2, and Th17 CD4 cells in the early post-transplantation period. In vitro graft replication studies confirmed that CD3/19D disproportionately depleted Tregs and other CD4 subset repertoires in the graft. This study confirms the utility of biomarker monitoring, which can be directly correlated with biological consequences and possible future therapeutic indications.     

Chiropractic management of postpartum pubic symphysis diastasis: A case report

This case report describes the chiropractic management of a 30-year-old female patient with severe postpartum pelvic pain secondary to pubic symphysis diastasis. No literature was found on the chiropractic management of postpartum symphysis pubis diastasis. The existing literature concerning chiropractic care for symphysis pubis dysfunction during pregnancy is limited and indicates a potential benefit. Separation of the pubic symphysis may include ligamentous injury to the sacroiliac joints and may lead to chronic pain. Pubic symphysis separation of 17 millimeters was present on digital radiograph. Management consisted of chiropractic adjustments, trigger point release, electrical stimulation, moist heat, sacroiliac belt, and specific stabilizing exercises. The patient’s pain improved immediately following treatment on the initial visit. Pain was reduced from 8/10 VAS at the first visit to 2/10 at the fourth visit. She was able to resume normal activities and reached a final pain level of 1/10. The diastasis was reduced by 7 millimeters at 14-weeks post radiograph for a final separation of just under 10 millimeters. Collaboration between obstetricians, midwives and chiropractors may be warranted.     

正骨手法治疗单纯收缩期高血压伴颈椎病的病例对照研究

目的:探索正骨手法治疗单纯性收缩期高血压伴随颈椎病的疗效及安全性。方法:自2012年1 月至2015 年1 月,收治单纯收缩期高血压伴颈椎病患者320 例,分为治疗组和对照组。治疗组160例,男84例,女76例,平均年龄(39.82±10.33)岁,平均血压(149.61±10.75)/(81.01±8.25) mmHg,NPQ评分24.61±8.14;对照组160例,男90例,女70例,平均年龄(41.37±9.42)岁,平均血压(151.48±11.32)/(79.65±9.32) mmHg,NPQ评分25.78±9.53.治疗组予颈椎屈顶旋锁定正骨手法治疗,每2日1次,连续20 d;对照组予坐位颈椎旋转复位法治疗,每2日1次,连续20 d.于治疗前后测量血压及填写NPQ量表以评估疗效。结果:治疗前及1个疗程结束后收缩压,治疗组分别为(149.61±10.75) mmHg和(129.67±12.26) mmHg,对照组分别为(151.48±11.32) mmHg和(132.02±11.73) mmHg,两组治疗后收缩压均较治疗前下降,治疗后治疗组收缩压改善优于对照组。治疗前后舒张压,治疗组分别为(81.01±8.25) mmHg和(78.15±10.34) mmHg,对照组分别为(79.65±9.32) mmHg和(76.89±9.79) mmHg,两组舒张压变化差异无统计学意义。治疗前后NPQ 评分,治疗组分别为24.61±8.14和12.46±7.94,对照组分别为25.78±9.53和14.17±8.86,两组治疗后评分均优于治疗前,治疗后两组评分差异无统计学意义。总体疗效比较,治疗组优于对照组。结论:单纯收缩期高血压伴颈椎病患者早期行正骨手法治疗效果显着,颈椎屈顶旋锁定正骨手法效果较传统坐位颈椎旋转复位法疗效更佳,更为安全。     

伸筋易骨矫形手法治疗KOA轻度内翻畸形的临床研究

[目的]分析伸筋易骨矫形手法治疗膝关节骨性关节炎(KOA)轻度内翻畸形的有效性。[方法]将70例KOA轻度内翻畸形患者随机分为两组。观察组采用伸筋易骨矫形手法治疗,对照组采用玻璃酸钠注射液关节腔注射治疗。两组均治疗21 d,分析治疗前后局部胫股力线解剖角(α角),膝关节功能积分,下肢力线偏移距离(L),下肢绝对长度(H),股四头肌、腘绳肌肌张力变化。[结果]两组治疗后膝关节功能、股直肌、腘绳肌肌肉张力均有显著提高(P0.05),观察组优于对照组(P0.05)。观察组α角和L显著减少(P0.05),对照组无明显变化(P0.05)。两组患者H均无明显变化(P0.05)。[结论]伸筋易骨矫形手法是治疗KOA轻度膝内翻畸形的有效方法,能够有效减小膝关节内翻畸形的角度,显著提高膝关节功能。     

推抹捏擦扳五步推拿法为主治疗周围性面瘫临床观察

目的观察推抹捏擦扳五步推拿法为主治疗周围性面瘫的临床疗效。方法将72例周围性面瘫患者随机分为治疗组与对照组,每组36例。在均使用红外线照射治疗的基础上,对照组加用常规针刺疗法,治疗组加用推抹捏擦扳五步推拿法。两组疗程均为10天,观察临床疗效,比较面神经功能分级的变化情况。结果 1治疗组、对照组总有效率分别为94.44%和83.33%,组间临床疗效比较差异有统计学意义(P0.05)。2治疗前后组内比较,两组面神经功能分级差异均有统计学意义(P0.05);组间治疗后比较,面神经功能分级差异有统计学意义(P0.05)。结论推抹捏擦扳五步推拿法为主治疗周围性面瘫疗效满意。